MD Anderson Cancer Center

Molecular Diagnostics & Therapeutics

Tumor Biology Lab

The research program we are actively pursuing is broad in its approach, but is focused upon a single goal. That goal is to improve the lot of the cancer patient. Ongoing aims of the research program include better understanding tumor biology, providing candidate genes for use in detection, diagnostic and prognostic signatures, developing novel algorithms for accurate analysis of high-throughput datasets, role of infection in cancer, and functional analysis of specific genes in tumor progression. These aims have spawned numerous innovative tangential projects along the way, but our overall goal is to use the information to develop improved cancer detection assays, and diagnostic/prognostic signatures for use in the clinical setting, and finally to aid the design and implementation of improved therapeutic strategies.

Studies will be focused on the study of three cancer systems: Breast, Prostate, and Bladder.

Project plans in each system are described below, but data from each project illuminates the others, and we have parallel technique-based programs that provide data that are applicable across all of these systems.




Publications
1.   Goodison S, Kenna S, Ashcroft SJH. Control of insulin gene expression by glucose. Biochem J 285: 563-568 (1992)

2.   Goodison S, Ashcroft SJH. Comparison of rat-I and human insulin gene 5' sequence-mediated transcriptional responses. Diabetic Medicine 9: 512-514, (1992)

3.   Goodison S, Ashcroft SJH. Human insulin promoter-driven reporter gene expression. Biochem Soc Trans 21: 225-226 (1992)

4.   Goodison S, Ashcroft SJH. Trans-acting factors and glucose-responsive transcriptional regulation in the insulin gene. In: Physiology and Pathophysiology of the Islets of Langerhans (ed: B Soria). Plenum Press 231- 237 (1994)

5.   German M, Ashcroft SJH, Docherty K, Goodison S, Rutter W., Steiner D, et al. The Insulin gene promoter. Diabetes: Vol 4, 1002-1005. (1995)

6.   Goodison S, Miyazaki J, Ashcroft SJH. Response to glucose of transcription binding in the rat insulin-I gene promoter. Biochem Biophys Res Comm 203: 702-710, (1994)

7.   Yoshida K, Bolodeoku J, Sugino T, Goodison S, Matsumura Y, Warren BF, Toge T, Tahara E, Tarin D. Abnormal retention of intron 9 in CD44 gene transcripts in human gastrointestinal tumors. Cancer Research 55, 4273-77 (1995)

8.   Yoshida K, Goodison S, Sugino T, Bolodeoku J, Churchman M, Warren B, Tarin D. Semi-quantitative detection of abnormal CD44 transcripts in colon carcinomas by RT-PCR- enzyme linked immunosorbant assay Molecular Diagnosis Vol 1, No 3 167-173 (1996)

9.   Sugino T, Yoshida K, Bolodeoku J, Tahara H, Buley I, Manek S, Wells C, Goodison S, Ide T, Suzuki T, Tahara E, Tarin D. Telomerase activity in human breast cancer and benign breast lesions: Diagnostic applications in clinical specimens including fine needle aspirates. International Journal of Cancer 69, 301-306 (1996)

10.   Goodison S, Yoshida K, Tarin D. CD44 intron retention in colonic tumour tissues. In: Recent Advances in Gastrolenterological Carcinogenesis. Published by Monduzzi Editore. Editors; Tahara E. and Oohara K.S. 977-982 (1996)

11.   Gorham H, Sugino T, Bolodeoku J, Yoshida K Goodison S, Tarin D Distribution of CD44 messenger RNA in archival paraffin wax embedded tumours and normal tissues viewed by in situ hybridisation. Journal of Clinical Pathology: Mol. Pathol. 49:147-50 (1996)

12.   Yoshida K., Sugino T., Bolodeoku J, Warren BF, Goodison S, Woodman A, Toge T, Tahara E, Tarin D. Detection of exfoliated carcinoma cells in colonic luminal washings by identification of deranged patterns of expression of the CD44 gene. Journal of Clinical Pathology 49, 300-305 (1996)

13.   Woodman AW, Sugiyama M, Yoshida K, Sugino T, Borgya A, Goodison S, Matsumura Y, Tarin D. Analysis of anomalous CD44 gene expression in human breast, bladder and colon cancer and correlation of observed mRNA and protein isoforms. American Journal of Pathology 149, No. 5, 1519-1530 (1996)

14.   Bolodeoku J, Yoshida K, Sugino T, Goodison S, Tarin D. Accumulation of immature intron-containing CD44 gene transcripts in breast cancer tissues. Molecular Diagnosis Vol 1, No. 3. 175-181 (1996)

15.   Sugino T, Gorham H, Yoshida K, Bolodeoku J, Nargund V, Cranston D, Goodison S, Tarin D. Progressive loss of CD44 gene expression in invasive bladder cancer. American Journal of Pathology 149:873-882, (1996)

16.   Yoshida K, Sugino T, Tahara H, Woodman A, Bolodeoku J, Nargund V, Fellows G, Goodison S, Tahara E, Tarin D. Telomerase activity in bladder carcinomas and its implications for non- invasive diagnosis by detection of exfoliated cancer cells in urine Cancer 79: 362-369 (1997)

17.   Yoshida K, Sugino T, Goodison S, Warren B, Nolan D,Wadsworth S, Mortensen NJ, Toge T, Tahara E, Tarin D. Detection of telomerase activity in exfoliated cancer cells in colonic luminal washings and its related clinical implications. British Journal of Cancer 75 (4), 548-553 (1997)

18.   Bolodeoku J, Yoshida K, Sugino T, Churchman M, Goodison S, Tarin D. CD44 variant gene transcripts in human breast carcinomas. Biochem. Soc. Trans. Vol 25, No. 2 356-357 (1997)

19.   Goodison S, Yoshida K, Sugino T, Woodman AW, Gorham H, Bolodeoku J, Kaufmann M, Tarin D. Rapid analysis of distinctive CD44 RNA splicing preferences that characterize colonic tumours. Cancer Research 57, 3140-3144 (1997)

20.   Sugino T, Yoshida K, Bolodeoku J, Tarin D, Goodison S. Telomerase activity and its inhibition in benign and malignant breast lesions. Journal of Pathology 183, 57-61 (1997)

21.   Goodison S, Ashcroft SJH. Trans-acting factor(s) confer glucose-responsive transcriptional regulation in the insulin gene. Adv Exp Med Biol 426: 97-101 (1997)

22.   Gorham H, Yoshida K, Sugino T, Marsh G, Charnock M, Tarin D, Goodison S. Telomerase activity in human gynaecological tissues. Journal of Clinical Pathology Vol 50, 501-504 (1997)

23.   Goodison S., and Tarin D The current status of CD44 variant isoforms as cancer diagnostic markers Histopathology 32: 1-6 (1998)

24.   Sugino T, Yoshida K, Zhao S, Goodison S, Tarin D. Disorderly CD44 gene expression in human cancer cells can be modulated by growth conditions. Journal of Pathology 186: 17-23 (1998)

25.   Goodison S., and Tarin D. Clinical implications of anomalous CD44 gene expression in neoplasia. Frontiers in Bioscience 3: 89-109 (1998)

26.   Aogi K, Kitihara K, Buley I, Tahara H, Sugino T, Tarin D, Goodison S. Telomerase activity in lesions of the thyroid: Application to diagnosis of clinical samples including fine needle aspirates. Clin Cancer Res 4: 1965-1970 (1998)

27.   Urquidi V, Tarin D and Goodison S. Telomerase in cancer: clinical applications. Annals of Medicine 30: 419-430 (1998)

28.   Goodison S, Yoshida K, Churchman M, Tarin D. Multiple intron-retention occurs in tumor cell CD44 mRNA processing. Am J Pathol 153(4):1221-8 (1998)

29.   Gorham H, Woodman A, Goodison S, Charnock M, Manek S, Sugino T, Tarin D. CD44 expression in human cervical intraepithelial neoplasia and carcinoma. Molecular Diagnosis Vol 4. No. 1, 45-57 (1999)

30.   Goodison S, Urquidi V, Tarin D The CD44 adhesion molecules. Molecular Patholog 52:1-7 (1999)

31.   Aogi K, Kitihara K, Urquidi V, Tarin D, Goodison S. Comparison of CD44 isoforms and telomerase activity as a diagnostic tumor marker in lesions of the thyroid. Clinical Cancer Res. 5(10):2790-7 (1999)

32.   Urquidi V, Tarin D, Goodison S. Role of telomerase in cell senescence and oncogenesis. Annual Rev. Medicine 51: 65-79 (2000)

33.   Woodman A, Goodison S, Drake M, Noble J, Tarin D. Non-invasive diagnosis of bladder carcinoma by detection of CD44 isoforms on exfoliated urothelia. Clin Cancer Res (6):2381-92. (2000)

34.   Aogi K, Woodman AC, Urquidi V, Mangham DC, Tarin D, Goodison S. Telomerase activity in soft tissue and bone sarcoma. Clin Cancer Res (6):4776-4781. (2000)

35.   Taniyama K, Goodison S, Ito R, Tarin D, Urquidi V. PTEN expression is maintained in sporadic colon cancer. J Pathol. (3):341-8 (2001)

36.   Hayashi K., Yokozaki H., Goodison S., Oue A., Suzuki T., Lotan R., Yasui W., Tahara E. Inactivation of retinoic acid receptor-beta by promoter CpG hypermethylation in gastric cancer. Differentiation Vol 68:13-21, (2001)

37.   Kawai K, Viars C, Arden K, Tarin D, Urquidi V, Goodison S. Comprehensive Karyotyping of the HT-29 colon carcinoma cell line. Genes, Chromosomes and Cancer Vol 34: 1-8, (2002)

38.   Urquidi V, Sloan D., Kawai K., Agarwal D., Woodman A., Tarin D., Goodison S. Contrasting Expression of Thrombospondin-1 and Osteopontin correlates with absence or presence of metastatic phenotype in an Isogenic Model of Spontaneous Human Breast Cancer Metastasis Clinical Cancer Research Vol 8:61-74, (2002)

39.   Sugino T, Kusakabe T, Hoshi N, Yamaguchi T, Goodison S, Sekimata M, Homma Y, Suzuki T An invasion-independent pathway of blood-borne dissemination : A new murine mammary tumor model of metastasis. American Journal of Pathology Vol 160 (6); 1973-1980, (2002)

40.   Agarwal D., Goodison S, Nicholson, B., Tarin D, Urquidi V. Representational Difference Analysis Reveals a Correlation between MMP8 Expression and Breast Cancer Metastasis. Differentiation 71(2):114-25 (2003)

41.   Hayashi K., Goodison S, Urquidi V, Tarin D., Lotan R., Tahara E. The effects of all-trans retinoic acid on the growth of matched metastatic and non-metastatic breast cancer cell lines. International Journal of Oncology 22(3):623-629 (2003)

42.   Goodison S, Kawai K, Hihara J, Jiang P, Yang M, Urquidi V, Hoffman R, Tarin D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein. Clinical Cancer Research 9:3808-3814 (2003)

43.   Ma H, Urquidi V, Kleeman J, Goodison S. Transcriptional Regulation of the hTERT gene during Human Muscle Cell Differentiation Molecular Cancer Research 10:739-46 (2003)

44.   J Wang-Rodriguez, V Urquidi, A Rivard, S Goodison. Elevated Osteopontin and Thrombospondin Expression Identifies Malignant Human Breast Carcinoma but is not Indicative of Metastatic Status Breast Cancer Research Vol 5:136-143 (2003)

45.   Goodison S, Viars C, Grazzini M and Urquidi V. The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines. BMC Genomics 4:39 (2003)

46.   Sloan DD, Nicholson BE, Urquidi V, Goodison S. Detection of differentially expressed genes in an isogenic breast metastasis model using RNA Arbitrarily Primed-PCR coupled with array hybridization (RAP-array) American Journal of Pathology 164(1): 315-23 (2004)

47.   RO Stuart, WWachsman, CC Berry, J Wang-Rodriquez, L Wasserman, I Klacansky, D Masys, K Arden, S Goodison, M McClelland, I Kalcheva, and D Mercola. In silico extraction of cell-type associated patterns of gene expression in prostate cancer. Proc. Natl. Acad. Sci. USA 101: 615-620 (2004)

48.   Kreunin P., Urquidi V., Lubman DL., and Goodison S. Identification of metastasis-associated proteins in a human tumor metastasis model using the mass-mapping technique. Proteomics 4(9):2754-65 (2004)

49.   Sugino T, Yamaguchi T, Ogura G, Saito A, Goodison S, Suzuki T. Morphological evidence for an invasion-independent metastatic pathway exists in multiple human cancers BMC Medicine 2;9-15 (2004)

50.   Bertholf RL., and Goodison S. Television viewing and attention deficits in children. Pediatrics 114(2):511-2. (2004)

51.   Goodison S., Viars C., Urquidi V. Molecular cytogenetic study of a human breast tumor metastasis model: Identification of phenotype-specific chromosomal rearrangements. Cancer Genetics and Cytogenetics 156; 37-48 (2005)

52.   Goodison, S Gene Expression Profiling of Breast Cancer in Ethnic Populations: An Aid to Gene Discovery for the Benefit of All. The Breast Journal 11(2):89-91 (2005)

53.   Goodison S, Yuan J, Sloan S, Kim R, Li C, Popescu N, Urquidi V. The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Research 65(14):6042-53 (2005)

54.   Khalbuss W., Ambaya A., Goodison S., Loya A., Masood S. Papillary carcinoma of the breast in a male patient with a treated prostatic carcinoma diagnosed by Fine Needle Aspiration Biopsy: A case report and review of the literature. Diagnostic Cytopathology 34(3):214-7 (2006)

55.   Khalbuss, W., Goodison S. Immunohistochemical detection of hTERT in urothelial lesions: a potential adjunct to urine cytology. Cytojournal. 3(1):18 (2006)

56.   Anai S, Goodison S, Shiverick K, Iczkowski K, Tanaka M, Rosser CJ. Combination of PTEN Gene Therapy and Radiation Inhibits the Growth of Human Prostate Cancer Xenografts. Hum Gene Ther. 17(10):975-84 (2006)

57.   Ranki T., Kanerva A., Sarkioja M., Kangasniemi L., Raki M., Laakkonen P., Goodison S., Hemminki A. A heparin sulphate targeted conditionally replicative adenovirus, Ad5.pK7-?24, for the treatment of advanced breast cancer. Gene Therapy 14(1):58-67. (2007)

58.   Sun Y, Goodison S, Li J, Liu L, Farmerie W Accurate Prediction of Breast Cancer Recurrence by combining Clinical and Genetic Markers Bioinformatics 23(1):30-7 (2007)

59.   Kreunin P, Chul Yoo, Virginia Urquidi, David M Lubman, Steve Goodison. Proteomic Profiling Identifies Breast Tumor Metastasis-Associated Candidates in an Isogenic Model. Proteomics 7(2):299-312 (2007)

60.   Rice L, Handayani R, Cui Y, Medrano T, Samedi V, Baker H, Szabo NJ, Goodison S, Rosser CJ, and Shiverick KT. Differential Effects of Soy Isoflavones on Androgen Responsive Genes in LNCaP Human Prostate Cancer Cells. Journal of Nutrition 137(4):964-972. (2007)

61.   Anai S, Tanaka M, Kim W, Takada S, Boehlein S, Goodison S, Shiverick K, Hirao Y, Rosser, CJ. Increased expression of Cox-2 correlates with resistance to radiation in human prostate adenocarcinoma cells. Journal of Urology 177(5):1913-7. (2007)

62.   Anai S, Goodison S, Shiverick K, Hirao Y, Brown B, and Rosser CJ. Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC3 prostate tumor xenografts. Molecular Cancer Therapeutics 6(1):101-11. (2007)

63.   Sugino T., Yamaguchi T., Ogura G., Kusakabe T., Goodison S., Homma Y., Suzuki T. The secretory leukocyte protease inhibitor (SLPI) suppresses cancer cell invasion but promotes blood-borne metastasis via an invasion-independent pathway Journal of Pathology 212(2):152-60 (2007)

64.   Anai S, Nakamura K, Goodison S, Shiverick K, Brown B, and Rosser CJ. Irradiation Increases Uptake of Fluorescently Labeled Antisense Oligodeoxynucleotide in Human Cancer Cells. Int. Journal of Radiation Oncology, Biology, Physics 68(4):1161-8 (2007)

65.   Kreunin P, Zhao J, Rosser CJ, Urquidi V, Lubman DM, Goodison S. Bladder Cancer Associated Glycoprotein Signatures revealed by Urinary Proteomic Profiling Journal of Proteome Research 6(7):2631-9. (2007)

66.   Goodison S, Nakamura K, Izckowski KA, Anai S, Boehlein SK, Rosser CJ. Gene Expression Changes Associated with Growth and Morphologic Effects of Mycoplasmal p37 on Prostate Cancer Cells. Cytogenetics and Genome Research 118(2-4):204-13.(2007)

67.   Anai S, Shiverick K, Medrano T, Nakamura K, Goodison S, Brown BD, Rosser CJ. Downregulation of Bcl-2 induces downregulation of carbonic anhydrase IX, VEGF and pAkt and induces radiation sensitization. Urology 70(4):832-7 (2007)

68.   Urquidi V and Goodison S. Genomic signatures of breast cancer progression Cytogenetics and Genome Research 118(2-4):116-29. (2007)

69.   Kreunin P; Chul Yoo; Virginia Urquidi; David M Lubman, Steve Goodison. Differential Expression of Ribosomal Proteins in a Human Tumor Metastasis Model Identified by Coupling 2-D Liquid Chromatography and Mass Spectrometry. Cancer Genomics and Proteomics 4 (5) 329-341 (2007)

70.   SunY and Goodison S Predicting Breast Cancer Metastasis by Integrating Both Clinical and Genetic Markers Proc. International Conference on Bioinformatics and Computational Biology (BIOCOMP'07), Vol. 1, 229-235 (2007)

71.   DM. Lubman, NS. Buchanan, P Kreunin, FR. Miller, K Cho, R Wu, S Goodison, and T J. Barder. A 2-Dimensional Liquid Mass Mapping Technique for Biomarker Discovery. In: Multidimensional Liquid Chromatography : Theory and Applications in Industrial Chemistry and the Life Sciences, Edited by Steven A. Cohen, Mark R. Schure. (2008)

72.   Shuja S, Mohammadi A, Grigorian S, Goodison S. Patterns of Cathepsin H Expression in Glioblastoma Multiforme. The Internet Journal of Pathology. Volume 7 Number 1. http://www.ispub.com (2008)

73.   Sun Y, Todorovic S, Goodison S A Feature Selection Algorithm Capable of Handling Extremely Large Data Dimensionality Proceedings of the 2008 SIAM International Conference on Data Mining pp530-541 (2008)

74.   Goodison S, Urquidi V. Breast Tumor Progression: Analysis via Proteomic Profiling Expert Reviews in Proteomics 5(3):457-67 (2008)

75.   Sugino T, Yamaguchi T, Hoshi N, Kusakabe, Go Ogura T, Goodison S, Suzuki T. Sinusoidal tumor angiogenesis is a key component in hepatocellular carcinoma metastasis. Clinical and Experimental Metastasis 25(7):835-41. (2008)

76.   Sun Y and Goodison S. Combining Nomogram and Microarray Data for Predicting Prostate Cancer Recurrence. Proceedings of the 8th IEEE International Conference on BioInformatics and BioEngineering IEEE BIBE 08’ :1-7 (2008)

77.   Wang Y, Ao X, Vuong H, Konanur M, Miller FR, Goodison S, Lubman DM. Membrane glycoproteins associated with breast tumor cell progression identified by a lectin affinity approach. Journal of Proteome Research 7(10):4313-25 (2008)

78.   Sippel KH, Robbins AH, Reutzel R, Domsic J, Boehlein SK, Agbandje-McKenna M, Goodison S, Rosser CJ, and McKenna R. Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37. Acta D Crystallography 64(Pt 11):1172-8 (2008)

79.   Sakai Y*, Goodison S*, Kusmartev S, Fletcher B, Cao W, Porvasnik S, Namiki K, Anai S, Rosser CJ. Bcl-2 mediated modulation of vascularization in prostate cancer xenografts. Prostate 69(5):459-470 (2008) (*equal contribution)

80.   Patwa TH, Y Wang, S Goodison, TJ Barder, FR Miller, DM Lubman Global phosphoprotein analysis for assessing changes in pre-malignant and malignant breast cell lines using 2D liquid separations, protein microarrays and tandem mass spectrometry Proteomics Clin Appl. 2008;3(1):51-66. (2008)

81.   CJ. Rosser, L Liu, Y Sun, M McCullers, S Porvasik, S Goodison. Bladder Cancer Associated Gene Expression Signatures Identified by Profiling of Exfoliated Urothelia. Cancer Epidemiology Biomarkers and Prevention 18(2):444-53 (2009)

82.   Koziol JA, Feng AC, Jia Z, Wang Y, Goodison S, McClelland M, Mercola D. The Wisdom of the Commons: Ensemble Tree Classifiers for Prostate Cancer Prognosis. Bioinformatics 25(1):54-60 (2009)

83.   Cai Y, Sun Y, Li J, and Goodison S Online Feature Selection Algorithm with Bayesian l1 Regularization Proc. 13th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD’09), pp. 401-413 (2009)

84.   Sippel KH, Robbins AH, Reutzel R, Boehlein SK, Namiki K, Goodison S, Agbandje-McKenna M, Rosser CJ, McKenna R. Structural insights of the Mycoplasma hyorhinis protein Mh-p37 Journal of Bacteriology 1(8):2585-92 (2009)

85.   Eiseler T, Döppler H, Yan IK, Goodison S, Storz P Protein Kinase D1 mediates the breast cancer cell invasive phenotype. Breast Cancer Research 11(1):R13 (2009)

86.   Sakai Y*, Goodison S*, Cao W, Namiki K, Porvasnik S, Rosser CJ. (*equal contribution) VEGF treatment of microvascular endothelial cells induces Bcl-2 expression and multiple signaling factors. World Journal of Urology (5):659-66 (2009)

87.   Sun Y, Goodison S* (*equal contribution). Optimizing Molecular Signatures for Predicting Prostate Cancer Recurrence The Prostate 69(10):1119-27 (2009)

88.   Anai S, Sakamoto N, Sakai Y, Tanaka M, Porvasnik S, Urbanek C, Cao W, Goodison S, Rosser CJ. Dual targeting Bcl-2 and VEGF: a potential strategy to improve therapy for prostate cancer. Urol Oncol 2009 Jul 2. [Epub ahead of print]

89.   Villicana P, Whiting B, Goodison S, Rosser CJ. Urine Based Assays for the Detection of Bladder Cancer Biomarkers in Medicine, Vol. 3(3): 265-274 (2009)

90.   Porvasnik S, Sakamoto N, Kusmartsev S, Kim WJ, Cao W, Urbanek C, Wong D, Goodison S, Rosser CJ. Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth. Prostate 69(13):1460-9 (2009)

91.   Feng S, Yang N, Pennathur S, Goodison S and Lubman DM Enrichment of Glycoproteins using Nano-scale Chelating Con A Monolithic Capillary Chromatography Annals of Chemistry 81(10):3776-83 (2009)

92.   Namiki K*, Goodison S*, Porvasnik S, Allan RW, Urbanek C, Reyes L, Sakamoto N, Rosser CJ Persistent exposure to mycoplasma induces malignant transformation of human prostate cells PlosOne 4(9):e6872 (2009) (*equal contribution)

93.   Goodison S, Rosser CJ and Urquidi V Urinary proteomic profiling for bladder cancer detection Expert Review of Proteomics (5):507-14 (2009)

94.   Layton T, Stalens C, Gunderson F, Goodison S, Silletti S The nonreceptor tyrosine kinase syk acts as a pancreatic adenocarcinoma tumor suppressor via regulation of gene expression and cellular invasion American Journal of Pathology 175(6):2625-36 (2009)

95.   Rosser CJ, Goodison S. CD24, a promising biomarker in NSCLC. Biomark Med. Aug;4(4):493-5 (2010)

96.   Sun Y, Urquidi Y and Goodison S Predicting Breast Cancer Metastasis by Integrating Both Clinical and Genetic Markers Breast Cancer Research and Treatment 119(3):593-9 (2010)

97.   Bandyopadhyay N, Kahveci T, Ranka S, Sun Y and Goodison S. Pathway based Feature Selection Algorithm for Cancer Microarray Data Advances in Bioinformatics ms# 532989. Epub Mar 3 (2010)

98.   Sun Y, Sinisa T, Goodison S. Local Learning Based Feature Selection for High Dimensional Data Analysis IEEE Trans. on Pattern Analysis and Machine Intelligence 32(9):1610-26 (2010)

99.   Rosser CJ, Goodison S. Novel approach for oral cancer biomarker discovery. Biomarkers in Medicine, Vol. 4, No. 4, Pages 495-497 (2010)

100.   Xie X, Feng S, Vuong H, Liu Y, Goodison S, Lubman DM A label-free quantitative analytical approach for phosphopeptide profiling Electrophoresis 31(11):1842-1852 (2010)

101.   Cai Y, Sun Y, Cheng Y, Li J, Goodison S Fast Implementation of l1 Regularized Learning Algorithms Using Gradient Descent Methods SIAM Data Mining April pp862-871 (2010).

102.   Goodison S, Sun Y, Urquidi V Derivation of Cancer Prognostic Signatures from Gene Expression Data. Bioanalysis 2(5):855-862 (2010)

103.   Rosser CJ, Goodison S. Today’s discoveries to tomorrow’s care: cancer biomarkers revisited Biomarkers in Medicine, Vol. 4, No. 4, Pages 491-493. (2010)

104.   Sun Y, Cai Y, Mai V, Farmerie W, Yu F, and Goodison S Advanced Computational Algorithms for Microbial Community Analysis Using Massive 16S rRNA Sequence Data Nucleic Acids Research (In Press)

105.   Lee CY, Marzan D, Goodison S, Silletti S. a2-integrin-dependent suppression of pancreatic adenocarcinoma cell invasion involves ectodomain regulation of kalliekrien-related peptidases. (Submitted)

106.   Rosser CJ, Goodison S. From gene to protein expression: improving prognostication of DCIS. Biomark Med. Aug;4(4):497-9 (2010)

107.   Sippel KH, Venakatakrishnan B, Boehlein SK, Sankaran B, Quirit J, Govindasamy L, Agbandje-McKenna M, Goodison S, Rosser CJ, McKenna R. Insights into mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein. Proteins 79(2):528-36. (2011)