21
AUG
2014
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Academic Clinical Research

There are many exciting research opportunities for residents in our program. The program's research curriculum is quite unique in that it gives residents the opportunity to conduct research based on their career aspirations, whether their interest is in becoming a full-time clinician, a clinician-educator or an academic researcher.

Clinical research is well integrated into the entire curriculum so residents learn the about research on a regular basis and are taught how to incorporate it into practice. Evidence-based medicine comes in the form of lectures, interactive discussions, reviewing articles in journal club as well as in clinical practice.

Resident Scholarly Project

All residents as part of RRC requirements are required to complete a scholarly project before graduation. Materials submitted for scholarly project must be of publishable quality. We encourage residents to begin preparing their scholarly projects early in their residency to provide ample time to complete these projects and are fully supported by the faculty. Residents are also encouraged to submit their work and to the annual scientific meetings of the Society for Academic Emergency Medicine (SAEM) and the American College of Emergency Physicians (ACEP). There are also opportunities for international meetings.

Ongoing Research

  • Cardiac Arrest
  • Predictors of Acute Poisoning
  • Radiation Exposure in ED Patients
  • Triage Protocols
  • Telemedicine in Disaster Medicine
  • Emergency Department Protocols
  • Prehospital Care/EMS
  • Resident Productivity
  • Ultrasound
  • The MATCH
  • Physician-Parent Communication
  • Sepsis
  • Traumatic Brain Injury
  • EKG interpretation
  • Resident Education
  • Antibiotic Use
  • Patient Care and Satisfaction
  • Capnography Use
  • Abscess Management

There are several ongoing federally funded research projects in the department. For example, the National Institutes of Health awarded a $2.5 million dollar grant to Orlando Health to study traumatic brain injury. Linda Papa, MD, director of academic clinical research and an emergency medicine physician, is the grant recipient and principal investigator in a study that is underway at Orlando Health's Level I Trauma Center, ORMC, to evaluate the role of serum biomarkers in traumatic brain injury (TBI). The goal of this study is to provide a blood test that could be used immediately after injury to diagnose and treat patients with TBI and provide physicians and researchers with the tools they need to improve patient care.

There is also an academic research fellowship available designed to provide training in clinical research for outstanding candidates who are interested in an academic research career as clinician scientists or clinical investigators.



Research Highlight



Biomarkers for Mild and Moderate Traumatic Brain Injury Study: A National Institutes of Health Sponsored Study

Each year in the United States there are at least 1.7 million people who sustain a Traumatic Brain Injury (TBI). Traumatic brain injury is also a leading cause of combat casualty. A blood test to determine injury severity after a head injury would be very useful. There are a number of organ-based diseases that use rapid serum-based biomarkers to guide diagnosis and treatment but no such rapid diagnostic biomarkers exist for TBI. Investigators in the Department  in the Department of Emergency Medicine at Orlando Regional Medical Center are currently conducting an R01 investigator-initiated study led by Dr. Linda Papa and sponsored by the National Institutes of Health, to translate a series of acute care biomarkers to the bedside for mild and moderate traumatic brain injuries. Preliminary studies confirmed that certain proteins are released into human serum following a TBI. These proteins are detectable in serum within an hour of injury and associated with measures of injury severity including GCS score, CT lesions and neurosurgical intervention. These results are undergoing clinical validation in a large cohort of trauma patients.

Links to Publications

Papa L, Lewis LM, Falk JL, Zhang Z, Silvestri S, Giordano P,  Brophy G, et al.  Elevated Levels of Serum Glial Fibrillary Acidic Protein Breakdown Products in Mild and Moderate Traumatic Brain Injury are Associated with Intracranial Lesions and Neurosurgical Intervention. Ann Emerg Med June 2012;59(6):471-83. [Abstract]

Papa L, Lewis L, Silvestri S, Falk JL, Giordano P, et al.  Serum Levels of Ubiquitin C-terminal Hydrolase Distinguish Mild Traumatic Brain Injury from Trauma Controls and are Elevated in Mild and Moderate Traumatic Brain Injury Patients with Intracranial Lesions and Neurosurgical Intervention.  J Trauma 2012 72(5):1335-1344.

Video

SBDP150 levels distinguish mild TBI from uninjured controls from Academic Emergency Medicine on Vimeo.


Plenary Papers SAEM 2011 from Academic Emergency Medicine on Vimeo.


Preliminary results from this study were presented at the Society for Academic Emergency Medicine Annual Scientific Meeting in 20ll and 2012.

If you have any questions regarding academic research in our department, please contact Linda Papa, MD at 407.237.6329 or email: Linda.papa@orlandohealth.com.